Thyroid Functions in Children with Cerebral Palsy and Effects of Phénobarbital on Thyroid Hormones

Thyroid function tests were performed on 44 patients with cerebral palsy (CP) and on 35 healthy children as the control group. In the panent group total triiodothyronin (TT3), total thyroxine (TT4), free triiodothyronin (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) levels were found in wholly normal ranges. These values have shown no significant difference with respect to those of die control group (p>0.05). It was snüdng that -13 %, 41 % and 55 % of the padents were under 3 percentile according to length, weight and head circumference respectively. Thyroid funcdon tests of the padents with growth retardation had no significant difference fr< m those of the controls and patients without growth retardation. Tne TT4 and FT4 leveis in the patients using phénobarbital were considerably lower than those that are not using it (p<0.05). However, there were no significant difference in two groups with respect to T3 and TSH levels.

Serebral palsi'li 44 hastada tiroid fonksiyon testleri tayin edildi. Kontrol grubu olarak 35 sağlam çocuk seçildi. Hasta grubunda T3, T4 ve TSH seviyeleri normal sınırlarda olup, kontrol grubuna göre aradaki fark istatistiksel olarak önemsizdi (p>0.05). Serebral palsi'li hastaların % 43'ü boyca, % 41'i ağırlıkça, % 55'i baş çevresi bakımından 3 persentilin altındaydı. Gelişme geriliği olan hastalarda tiroid fonksiyon testleri kontrol grubuna göre önemli bir farklılık göstermedi (p>0.05). Antikonvülzan olarak phenobarbital alan hastalarda TT4 ve FT4 değerleri ilaç almayanlara göre anlamlı olarak düşüktü (p0.05).