Objective –The aim of this study was to evaluate the effects of local resveratrol
(RSVL) administration on bone formation in response to expansion of the interpremaxillary
suture, in rats.
Material and Methods – Twenty 50- to 60-day-old male Wistar rats were separated
into two equal groups. Both groups were subjected to expansion, and 30 cN of force
was applied to the maxillary incisors with helical-spring. Twenty-four hours after
appliance placement, single-dose 10 lmol ⁄ kg RSVL in the dimethylsulfoxide
(DMSO) was injected to the inter-premaxillary suture in the experimental group. In
the control group, the same amount of DMSO was injected to the suture of rats. Bone
formation in the suture was evaluated histomorphometrically. The area of new bone
(lm2), the perimeter around the new bone (lm), Feret s diameter (lm), the
percentage of new bone to non-ossified tissue (%), and the number of osteoblast
were measured and compared. Mann–Whitney U-test was used for statistical
evaluation at p < 0.05 level.
Results – Statistically significant differences were found between the groups for all
histomorphometric parameters. New bone area (p < 0.001), bone perimeter
(p < 0.001), Feret s diameter (p < 0.001), percentage of new bone (p < 0.001), and
the number of osteoblast (p < 0.001) were significantly larger in the experimental
group when compared with the control. Bone histomorphometric measurements
revealed that bone architecture in the RSVL treated rats was improved.
Conclusions – Local application of RSVL during the early stages to orthopedically
expanded inter-premaxillary suture area may stimulate bone formation and shorten
the retention period, in rats.
Eser Adı (dc.title) | Effect of resveratrol on bone formation in the expanded inter-premaxillary suture: early bone changes |
Eser Sahibi (dc.contributor.author) | TANCAN UYSAL |
Yayın Tarihi (dc.date.issued) | 2011 |
Diğer Yazarlar (dc.contributor.authors) | AHMET YAĞCI |
Diğer Yazarlar (dc.contributor.authors) | SERKAN GÖRGÜLÜ |
Diğer Yazarlar (dc.contributor.authors) | YILDIRIM KARSLIOĞLU |
Diğer Yazarlar (dc.contributor.authors) | D. SAĞDIÇ |
Diğer Yazarlar (dc.contributor.authors) | Ö. GÜNHAN |
Yayıncı (dc.publisher) | ORTHODONTICS & CRANIOFACIAL RESEARCH |
Tür (dc.type) | Makale |
Özet (dc.description.abstract) | Objective –The aim of this study was to evaluate the effects of local resveratrol (RSVL) administration on bone formation in response to expansion of the interpremaxillary suture, in rats. Material and Methods – Twenty 50- to 60-day-old male Wistar rats were separated into two equal groups. Both groups were subjected to expansion, and 30 cN of force was applied to the maxillary incisors with helical-spring. Twenty-four hours after appliance placement, single-dose 10 lmol ⁄ kg RSVL in the dimethylsulfoxide (DMSO) was injected to the inter-premaxillary suture in the experimental group. In the control group, the same amount of DMSO was injected to the suture of rats. Bone formation in the suture was evaluated histomorphometrically. The area of new bone (lm2), the perimeter around the new bone (lm), Feret s diameter (lm), the percentage of new bone to non-ossified tissue (%), and the number of osteoblast were measured and compared. Mann–Whitney U-test was used for statistical evaluation at p < 0.05 level. Results – Statistically significant differences were found between the groups for all histomorphometric parameters. New bone area (p < 0.001), bone perimeter (p < 0.001), Feret s diameter (p < 0.001), percentage of new bone (p < 0.001), and the number of osteoblast (p < 0.001) were significantly larger in the experimental group when compared with the control. Bone histomorphometric measurements revealed that bone architecture in the RSVL treated rats was improved. Conclusions – Local application of RSVL during the early stages to orthopedically expanded inter-premaxillary suture area may stimulate bone formation and shorten the retention period, in rats. |
Kayıt Giriş Tarihi (dc.date.accessioned) | 19.06.2014 |
Açık Erişim Tarihi (dc.date.available) | 2014-06-19 |
Yayın Dili (dc.language.iso) | eng |
Konu Başlıkları (dc.subject) | Image analysis |
Konu Başlıkları (dc.subject) | Maxillary expansion |
Konu Başlıkları (dc.subject) | Osteogenesis |
Konu Başlıkları (dc.subject) | Rats |
Konu Başlıkları (dc.subject) | Resveratrol |
Atıf için Künye (dc.identifier.citation) | Uysal, T., Gorgulu, S., Yagci, A., Karslioglu, Y., Gunhan, O., Sagdic, D. (2011). Effect of resveratrol on bone formation in the expanded inter-premaxillary suture: early bone changes. Orthod Craniofac Res. 14 (2), 80-87. doi: 10.1111/j.1601-6343.2011.01511.x. |
ISSN (dc.identifier.issn) | 1601-6343 |
Yayının ilk sayfa sayısı (dc.identifier.startpage) | 80 |
Yayının son sayfa sayısı (dc.identifier.endpage) | 87 |
Dergi Adı (dc.relation.journal) | ORTHODONTICS & CRANIOFACIAL RESEARCH |
Dergi Sayısı (dc.identifier.issue) | 2 |
Dergi Cilt (dc.identifier.volume) | 14 |
Veritabanı (dc.source.database) | Hiçbiri |
Haklar (dc.rights) | Open access |
Tek Biçim Adres (dc.identifier.uri) | Http://hdl.handle.net/11469/213 |