OPG and RANKL levels around miniscrew implants during orthodontic tooth movement

Introduction: The aim of this study was to determine the peri-miniscrew implant crevicular fluid receptor
activator of nuclear factor-lB ligand (RANKL) and osteoprotegerin (OPG) levels around loaded and unloaded
miniscrew implants at different time intervals. Methods: Twenty loaded and 16 unloaded miniscrew implants
were included in this study. All miniscrew implants were placed bilaterally between the maxillary second premolars
and first molars as anchorage units for canine distalization. Peri-miniscrew implant crevicular fluid was taken
from the mesiobuccal aspects of the loaded and unloaded miniscrew implants before loading; at 24, 48, and 168
hours; and on day 30 after force application. Enzyme-linked immunosorbent assay kits were used to determine
RANKL and OPG levels in the peri-miniscrew implant crevicular fluid samples. Wilcoxon, Mann-Whitney U, and
Spearman correlation tests were used for statistical evaluations at the P\0.05 level. Results: Although the total
amount of OPG was not different between the groups, the total amount of RANKL was significantly elevated in
the loaded miniscrew implant group (P\0.05) at all time periods. Peri-miniscrew implant crevicular fluid volume
was the highest at 48 hours in the loaded group. Also, the OPG/RANKL ratio in the peri-miniscrew implant
crevicular fluid was significantly decreased in the loaded miniscrew implant group. Conclusions: The OPG
and RANKL levels vary around loaded and unloaded miniscrew implants as a result of force application.

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Eser Adı
(dc.title)
OPG and RANKL levels around miniscrew implants during orthodontic tooth movement
Eser Sahibi
(dc.contributor.author)
İLKNUR VELİ
Eser Sahibi
(dc.contributor.author)
ŞÜKRÜ ENHOŞ
Yayın Tarihi
(dc.date.issued)
2013
Diğer Yazarlar
(dc.contributor.authors)
TANCAN UYSAL
Diğer Yazarlar
(dc.contributor.authors)
FARUK İZZET UYSAL
Diğer Yazarlar
(dc.contributor.authors)
ÖMER ÇAKMAK
Diğer Yazarlar
(dc.contributor.authors)
ARZU ALKAN
Yayıncı
(dc.publisher)
American Journal of Orthodontics and Dentofacial Orthopedics
Tür
(dc.type)
Makale
Özet
(dc.description.abstract)
Introduction: The aim of this study was to determine the peri-miniscrew implant crevicular fluid receptor activator of nuclear factor-lB ligand (RANKL) and osteoprotegerin (OPG) levels around loaded and unloaded miniscrew implants at different time intervals. Methods: Twenty loaded and 16 unloaded miniscrew implants were included in this study. All miniscrew implants were placed bilaterally between the maxillary second premolars and first molars as anchorage units for canine distalization. Peri-miniscrew implant crevicular fluid was taken from the mesiobuccal aspects of the loaded and unloaded miniscrew implants before loading; at 24, 48, and 168 hours; and on day 30 after force application. Enzyme-linked immunosorbent assay kits were used to determine RANKL and OPG levels in the peri-miniscrew implant crevicular fluid samples. Wilcoxon, Mann-Whitney U, and Spearman correlation tests were used for statistical evaluations at the P\0.05 level. Results: Although the total amount of OPG was not different between the groups, the total amount of RANKL was significantly elevated in the loaded miniscrew implant group (P\0.05) at all time periods. Peri-miniscrew implant crevicular fluid volume was the highest at 48 hours in the loaded group. Also, the OPG/RANKL ratio in the peri-miniscrew implant crevicular fluid was significantly decreased in the loaded miniscrew implant group. Conclusions: The OPG and RANKL levels vary around loaded and unloaded miniscrew implants as a result of force application.
Kayıt Giriş Tarihi
(dc.date.accessioned)
17.06.2014
Açık Erişim Tarihi
(dc.date.available)
2014-06-17
Yayın Dili
(dc.language.iso)
eng
Konu Başlıkları
(dc.subject)
OPG
Konu Başlıkları
(dc.subject)
Orthodontic tooth movement
Konu Başlıkları
(dc.subject)
Implants
Atıf için Künye
(dc.identifier.citation)
Enhos, S., Veli, I., Cakmak, O., Ucar, F.I., Alkan, A., Uysal, T. (2013). OPG and RANKL levels around miniscrew implants during orthodontic tooth movement. Ajo-Do, 144 (2), 203-209. doi: 10.1016/j.ajodo.2013.02.028.
ISSN
(dc.identifier.issn)
0889-5406
Yayının ilk sayfa sayısı
(dc.identifier.startpage)
203
Yayının son sayfa sayısı
(dc.identifier.endpage)
209
Dergi Sayısı
(dc.identifier.issue)
2
Dergi Cilt
(dc.identifier.volume)
144
Haklar
(dc.rights)
Open access
Tek Biçim Adres
(dc.identifier.uri)
Http://hdl.handle.net/11469/181
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