3D (Dimensional) microtissues are commonly used in regenerative medicine, medicine design, toxicology studies and advance cancer research. Microtissues which are constructed by this technique mimic natural in vivo condition and it stands for shifting form between in vitro studies and in vivo research. Scaffold-free microtissues produce own extracellular matrix and cells proliferate faster. However microtissue is used in vitro experiments, they mimic in vivo condition by producing own matrix.
Recently, RGD peptides which are commonly used biomaterials consist of GRGDS sequences and it has acti ...Daha fazlası
Within the scope of the thesis study, interpolation methods used for evaluating spatially varying data and for presenting the information obtained from the data via maps were investigated. A method for generating an open source web based interpolation map for the most commonly used interpolation methods is presented. Today, many commercial Geographic Information Systems (GIS) software are used in the production of interpolation maps. However, this situation causes the users to pay a large amount of money or use cracked programs. Although there are open source softwares, which can create interp ...Daha fazlası
The goal of this study is developing custom designed optical tweezer which uses two
He-Ne lasers (λ=632.8 nm) parallel to each other to trap yeast cells. The
characteristic specs of this optical tweezer determined by Brownian Motion of
polystyrene beads in water. Stiffness and trapping forces of optical tweezer
calculated for laser 1, laser 2 and when both lasers used simultaneously. Laser 2 can
trap and move particle to laser 1 and multiple particles can be trapped by the laser 1.
After determination of specs of optical tweezer, yeast cells in yogurt culture medium
were trapped by lase ...Daha fazlası
ABSTRACTIt is not possible to produce steel without inclusions as the process for steel production requires. Based on this fact, the researches on clean steel are concentrated on the reduction of inclusions and transformation of inclusions into harmless state by modification. The definition of steel cleanness is related to final product application. Non-metallic inclusion, in the liquid steel, causing many problems and production lost in steel production process and final application. Aluminum killed steels mostly contain Al2O3 and MnS inclusions. Al2O3 inclusions are formed during de-oxidatio ...Daha fazlası
Today, tissue transplant applications are widely used for repair of damaged hard tissue. Despite the gold standard of autografts, interest in synthetic bone grafts produced by tissue engineering techniques is increasing day by day, due to limiting factors such as damage to the tissue site and limited graft availability in allografts, and the risk of developing an immune system response in allografts.Many bioceramic materials, including β-tricalcium phosphate (β-TCP), hydroxyapatite (HA) and calcium sulfate, are widely used in bone tissue engineering. β-TCP has been the most preferred biocerami ...Daha fazlası
Graphene, a one-atom-thick two-dimensional material, has drawn great interest for many electronic and optoelectronic applications due to its extraordinary properties. The properties of the graphene can be modified with different chemical methods and introduced new properties, which widens its potential for applications. The non-covalent modification of graphene is one of the basic techniques for modifying the electrical properties of graphene without disrupting the structure.
In this thesis, the high-quality graphene has been synthesized and electrical properties of graphene have been tuned b ...Daha fazlası
ABSTRACTDiabetes Mellitus (DM) is a chronic disease that progresses rapidly. Today, thenumber of diabetic patients is increasing day by day, but treatment methods arebeginning to be inadequate due to the insufficient time, financial deficiencies andother restrictions. Diabetes education and treatment are very important for thediabetic to survive. Diabetes treatment is practiced in many areas of life from thenutrition habits to the social life activities. In terms of the course of diabetestreatment, it is necessary for the self-management of the patient to follow thediabetes education and appli ...Daha fazlası
ABSTRACTCities that have a history as a capital or an important trade center, has its own complex structure. If the historical city center was functionalized as a commercial district, it has been experienced social, cultural, environmental and economical subjects throughout centuries. This situation creates strong impacts as newly created contexts likewise political, public and architectural. These contexts generally not thought together, but they should be analyzed and investigated together for a sustainable future for the historical city centers. As a historical city center, Kemeralti-Izmir ...Daha fazlası
ABSTRACTCreating a tissue or an organ model is the most emerging field of the biomedical research for the last decades. Three-dimensional scaffolds that will mimic the extracellular matrix were designed and used in various applications to investigate the behavior of cells.In this study, both the synthesis of the polymer and the fabrication of three-dimensional hydrogel scaffolds were practiced. Gelatin methacrylate (GelMA) was synthesized prior to photopolymerization of the hydrogel. A novel scaffold fabrication device was designed and manufactured. This device allowed us fabricating computer ...Daha fazlası
This thesis focuses on a Multileaf Collimator design that can shape the beam contour to fit the shape of target geometry and its design improvements. Main purpose of this design is lowering the number of leaves on the multileaf collimator and making the system easier to be controlled. As the Collimator devices undertake the most important point of the beam shaping procedure, ease of control and precision of collimator devices are the major points of operation.
As the radiation therapy is one of the most complex and vital medical operations, this thesis started with the deep literature survey ...Daha fazlası
ABSTRACTCancer studies continue to gain interest in the recent period. Many types of cancer,especially breast cancer, continue to cause deaths worldwide and the number of people suffering from this disease is increasing. The methods that are used most at the basis of cancer studies are starting with 2-Dimensional (2D) cell culture. However, 2D cell culture can no longer adequately reflect in vivo conditions. Scientists have turned their efforts towards these 3-Dimensional (3D) cell cultures. There are many different ways of obtaining 3D cell culture. The preferred 3DPetriDish ™ technique in th ...Daha fazlası
ABSTRACTPreterm newborns are unlikely to live without any additional support. Babies born in this way need special care and a place that would imitate their mother’s womb as much as possible. The environmental conditions like the temperature, humidity, noise, light intensity, etc. need to be carefully managed. In addition to managing the environment, it is necessary to record vital data such as baby's temperature and pulse and record any changes so that they can be examined later. Since the systems that carry out these mentioned controls are very expensive, there are still hospitals that do no ...Daha fazlası
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.